Skip to Content
MilliporeSigma

Key Documents

View All Documentation

T0273

N-p-Tosyl-Gly-Pro-Arg 7-amido-4-methylcoumarin hydrochloride

protease substrate

Synonym(s):

N-(p-Tosyl)-Gly-Pro-Arg-AMC, Tos-Gly-Pro-Arg-AMC

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C30H37N7O7S · HCl
CAS Number:
117961-27-0
Molecular Weight:
676.18
NACRES:
NA.32
PubChem Substance ID:
24899877
UNSPSC Code:
12352204
MDL number:
MFCD00152182
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

acetic acid: 10 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cl.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc3ccc4C(C)=CC(=O)Oc4c3

InChI

1S/C30H37N7O7S.ClH/c1-18-7-10-21(11-8-18)45(42,43)34-17-26(38)37-14-4-6-24(37)29(41)36-23(5-3-13-33-30(31)32)28(40)35-20-9-12-22-19(2)15-27(39)44-25(22)16-20;/h7-12,15-16,23-24,34H,3-6,13-14,17H2,1-2H3,(H,35,40)(H,36,41)(H4,31,32,33);1H/t23-,24-;/m0./s1

InChI key

SRRKKDQGNHCPIE-UKOKCHKQSA-N

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
049H0595
095H0275
088H0901
078H1332
015H0187

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Protocols

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

V A Kuznetsov et al.
Laboratornoe delo, (8)(8), 43-45 (1990-01-01)
Toz-Gly-Pro-Arg-4-methylcoumaryl-7-amide is recommended for antithrombin-III (AT-III) photometry as a substrate. This substrate is cleaved by thrombin at 366 nm. AT-III photometry with this substrate is in accord with the requirements to methods used in clinical laboratory diagnosis, and the results
A Pasternak et al.
Biochemistry, 37(46), 16201-16210 (1998-11-18)
The zymogen and mature enzyme forms of trypsin-like serine proteases exhibit a wide range of activities. The prototypical trypsinogen-trypsin system is an example of a minimally active zymogen and a maximally active mature protease. The present work identifies several features
Efrat Shavit-Stein et al.
PloS one, 14(7), e0219453-e0219453 (2019-07-06)
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in diabetic neuropathy. We measured thrombin
View All Related Papers

Global Trade Item Number

SKUGTIN
T0273-10MG04061832910246