PCBP2
poly(rC) binding protein 2
Synonyms:
HNRNPE2, HNRPE2, hnRNP-E2
Species:
Human PCBP2 (5094), Mouse Pcbp2 (18521), Rat Pcbp2 (363005), Zebrafish pcbp2 (321844), Horse PCBP2 (100062163), domestic cat PCBP2 (101086733), dog PCBP2 (477596), naked mole-rat Pcbp2 (101702918), domestic guinea pig Pcbp2 (100731593), cow PCBP2 (540653)
UniProtKB ID:
Gene ID:
- Human(5094) Summary: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(18521) poly(rC) binding protein 2
- Rat(363005) poly(rC) binding protein 2
- Zebrafish(321844) poly(rC) binding protein 2
- Horse(100062163) poly(rC) binding protein 2
- domestic cat(101086733) poly(rC) binding protein 2
- dog(477596) poly(rC) binding protein 2
- naked mole-rat(101702918) poly(rC) binding protein 2
- domestic guinea pig(100731593) poly(rC) binding protein 2
- cow(540653) poly(rC) binding protein 2
- sheep(101103142) poly(rC) binding protein 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PCBP2 (AB2) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-PCBP2 (AB1) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, guinea pig, horse, human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-PCBP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-PCBP2 antibody produced in mouse, clone 3A1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Monoclonal Anti-PCBP2 antibody produced in mouse, clone 5F12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot