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Merck

U1752

Sigma-Aldrich

Uridine 5′-monophosphate

≥98%, natural (organic), powder

동의어(들):

U 5′-P, UMP, Uridylic acid

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C9H13N2O9P
CAS 번호:
58-97-9
Molecular Weight:
324.18
EC Number:
200-408-0
MDL number:
MFCD00067346
UNSPSC 코드:
41106305
PubChem Substance ID:
24900628
NACRES:
NA.51

주요 문서

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제품 이름

Uridine 5′-monophosphate, ≥98%

생물학적 소스

natural (organic)

Quality Level

200

분석

≥98%

양식

powder

solubility

H2O: soluble 50 mg/mL, clear, colorless

저장 온도

−20°C

SMILES string

OC1C(O)C(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O

InChI

1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)

InChI key

DJJCXFVJDGTHFX-UHFFFAOYSA-N

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관련 카테고리

일반 설명

Uridine 5′-monophosphate acts as a precursor for all pyrimidine nucleotides.

애플리케이션

Uridine 5′-monophosphate has been used as a component in isotonic E3 medium for isotonic reconstitution experiments to study its effects on the basal cell response or epithelial cell migration to the wound in the isotonic medium.

생화학적/생리학적 작용

Uridine 5′-monophosphate (UMP) is a nucleotide monomer in RNA. It contains the nucleobase uracil along with the ribose sugar and a phosphate group. UMP dietary supplementation enhances neurotransmitter release and neurite outgrowth and also promotes membrane phosphatide production in adult rats. Oral supplementation of DHA, co-administered with UMP, in adult gerbils shows an increase in dendritic spines and neuronal membrane synthesis. It suggests a strategy for the treatment of cognitive disorders resulting from synapse loss.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
SLCL9143
SLCL5733
SLCH2001
SLCG7290
SLCG6212

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문서 라이브러리 방문

Nezam Afdhal et al.
The New England journal of medicine, 370(16), 1483-1493 (2014-04-15)
Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients who have not had a sustained virologic response to prior interferon-based therapy represents an unmet medical need. We conducted a phase 3, randomized, open-label study involving patients infected
Edward J Gane et al.
The New England journal of medicine, 368(1), 34-44 (2013-01-04)
The standard treatment for hepatitis C virus (HCV) infection is interferon, which is administered subcutaneously and can have troublesome side effects. We evaluated sofosbuvir, an oral nucleotide inhibitor of HCV polymerase, in interferon-sparing and interferon-free regimens for the treatment of
Toshimasa Sakamoto et al.
Brain research, 1182, 50-59 (2007-10-24)
Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulating or brain DHA are associated with various neurocognitive disorders including Alzheimer's disease (AD), while
Regulation of uridylic acid biosynthesis in the cyanobacterium Anabaena variabilis.
Currier TC and Wolk CP
Journal of Bacteriology, 136(2), 682-687 (1978)
Lei Wang et al.
Journal of molecular neuroscience : MN, 27(1), 137-145 (2005-08-02)
Membrane phospholipids like phosphatidylcholine (PC) are required for cellular growth and repair, and specifically for synaptic function. PC synthesis is controlled by cellular levels of its precursor, cytidine-5'-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. In
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