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Merck

N3501

Sigma-Aldrich

β-Nicotinamide mononucleotide

≥95% (HPLC)

동의어(들):

β-NMN, β-Nicotinamide ribose monophosphate, NMN, Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C11H15N2O8P
CAS 번호:
Molecular Weight:
334.22
Beilstein:
3570187
EC Number:
MDL number:
UNSPSC 코드:
41106305
PubChem Substance ID:
NACRES:
NA.51
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Quality Level

분석

≥95% (HPLC)
≥95% (spectrophotometric assay)

양식

powder

solubility

H2O: soluble-50 mg/mL to clear, colorless to faintly yellow

저장 온도

−20°C

SMILES string

C[C@H]1[C@@H](C)[C@@H](O[C@@H]1COP(O)([O-])=O)[n+]2cccc(c2)C(N)=O

InChI

1S/C13H19N2O6P/c1-8-9(2)13(21-11(8)7-20-22(17,18)19)15-5-3-4-10(6-15)12(14)16/h3-6,8-9,11,13H,7H2,1-2H3,(H3-,14,16,17,18,19)/t8-,9+,11+,13+/m0/s1

InChI key

YYNOOWWEYJELSF-SEMCEJNYSA-N

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일반 설명

β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.

애플리케이션

β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.

기타 정보

Note: This is the common form of NMN. Do not confuse it with α-NMN.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Zheng-Hu Shi et al.
Scientific reports, 7(1), 8041-8041 (2017-08-16)
Metanephrines (MNs) were suggested as a potential first-line biochemical index for the diagnosis of phaeochromocytomas (PHEO). In this study, we developed a simple electrochemical method for the quantitative measurement of MNs in spot urine samples. As MNs contain a hydroxyphenyl
Gerwyn Morris et al.
Progress in neuro-psychopharmacology & biological psychiatry, 95, 109708-109708 (2019-07-28)
Major antioxidant responses to increased levels of inflammatory, oxidative and nitrosative stress (ONS) are detailed. In response to increasing levels of nitric oxide, S-nitrosylation of cysteine thiol groups leads to post-transcriptional modification of many cellular proteins and thereby regulates their
Shin-Ichiro Imai
Pharmacological research, 62(1), 42-47 (2010-01-21)
Aging science has recently drawn much attention, and discussions on the possibility of anti-aging medicine have multiplied. One potential target for the development of anti-aging drugs is the SIR2 (silent information regulator 2) family of NAD-dependent deacetylases/ADP-ribosyltransferases, called "sirtuins." Sirtuins
Jun Yoshino et al.
Cell metabolism, 14(4), 528-536 (2011-10-11)
Type 2 diabetes (T2D) has become epidemic in our modern lifestyle, likely due to calorie-rich diets overwhelming our adaptive metabolic pathways. One such pathway is mediated by nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD(+) biosynthesis, and the NAD(+)-dependent
João Meireles Ribeiro et al.
Scientific reports, 8(1), 1036-1036 (2018-01-20)
Cyclic ADP-ribose (cADPR) is a messenger for Ca

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