L4762

Loperamide hydrochloride

Name: Loperamide hydrochloride
Brand: SIGMA

98-102% (USP), powder, Ca2+ channel blocker

동의어(들):

4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₉H₃₃ClN₂O₂ · HCl

CAS 번호:

34552-83-5

Molecular Weight:

513.50

EC Number:

252-082-4

MDL number:

MFCD00058581

UNSPSC 코드:

12352200

PubChem Substance ID:

24278042

NACRES:

NA.77

주요 문서

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제품 이름

Loperamide hydrochloride,

Quality Level

200

주관자

Johnson & Johnson

SMILES string

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

InChI

1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

InChI key

PGYPOBZJRVSMDS-UHFFFAOYSA-N

유전자 정보

human ... OPRM1(4988)

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애플리케이션

Loperamide hydrochloride (HCl) has been used in inflammatory pain experiments and to assess the functionality of proteins. 54

생화학적/생리학적 작용

Loperamide hydrochloride (HCl) is a non-selective Ca²⁺ channel blocker. At nanomolar concentrations, it binds to μ-opioid receptors. Loperamide HCl does not cross the blood-brain barrier.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

Slightly soluble in water and dilute acids, freely soluble in methanol and in chloroform, soluble in ethanol (95%).

픽토그램

GHS06

신호어

Danger

유해 및 위험 성명서

H301

예방조치 성명서

P264 - P270 - P301 + P310 + P330 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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문서 라이브러리 방문

Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons.

J Church et al.

Molecular pharmacology, 45(4), 747-757 (1994-04-01)

The effects of the antidiarrheal agent loperamide on high-voltage-activated (HVA) calcium channel activity and excitatory amino acid-evoked responses in two preparations of cultured hippocampal pyramidal neurons were examined. In rat hippocampal neurons loaded with the calcium-sensitive dye fura-2, rises in

Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice.

Raphaël Weibel et al.

PloS one, 8(9), e74706-e74706 (2013-09-27)

Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach to

Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.

D L DeHaven-Hudkins et al.

The Journal of pharmacology and experimental therapeutics, 289(1), 494-502 (1999-03-23)

The antihyperalgesic properties of the opiate antidiarrheal agent loperamide (ADL 2-1294) were investigated in a variety of inflammatory pain models in rodents. Loperamide exhibited potent affinity and selectivity for the cloned micro (Ki = 3 nM) compared with the delta

The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria.

Olivia Benguettat et al.

PLoS pathogens, 14(9), e1007279-e1007279 (2018-09-05)

The digestive tract is the first organ affected by the ingestion of foodborne bacteria. While commensal bacteria become resident, opportunistic or virulent bacteria are eliminated from the gut by the local innate immune system. Here we characterize a new mechanism

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation.

Tamara Casteels et al.

Molecular metabolism, 54, 101329-101329 (2021-08-29)

The loss of forkhead box protein O1 (FoxO1) signaling in response to metabolic stress contributes to the etiology of type II diabetes, causing the dedifferentiation of pancreatic beta cells to a cell type reminiscent of endocrine progenitors. Lack of methods

모든 관련된 서류 보기

문서

Using Human iPS Cell-derived Colon Organoids for Cytotoxicity Screening of Drug Compounds

Human epithelial intestinal colonic organoids can be used as an alternative to Caco-2 drug permeability assays for drug screening and compound toxicity testing.

Discover Bioactive Small Molecules for ADME/Tox

Loperamide hydrochloride

98-102% (USP), powder, Ca2+ channel blocker

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

Quality Level

주관자

SMILES string

InChI

InChI key

유전자 정보

관련 카테고리

설명

애플리케이션

생화학적/생리학적 작용

특징 및 장점

제조 메모

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

개인 보호 장비

문서

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