G6025

Geranylgeranyl pyrophosphate ammonium salt

Name: Geranylgeranyl pyrophosphate ammonium salt
Brand: SIGMA

solution, ≥95% (TLC), ~1 mg/mL in methanol: NH₄OH (7:3)

동의어(들):

GGPP, all trans-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl pyrophosphate ammonium salt

로그인조직 및 계약 가격 보기

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₀H₃₆O₇P₂ · xNH₃

CAS 번호:

6699-20-3

Molecular Weight:

450.44 (free acid basis)

MDL number:

MFCD00156114

UNSPSC 코드:

12352211

PubChem Substance ID:

24895243

NACRES:

NA.77

주요 문서

모든 문서 보기

기술 서비스

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도움 문의

기술 서비스

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도움 문의

Quality Level

200

분석

≥95% (TLC)

양식

solution

포장

vial of 200 μg

농도

~1 mg/mL in methanol: NH₄OH (7:3)

저장 온도

−20°C

SMILES string

C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O

InChI

1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+

InChI key

OINNEUNVOZHBOX-QIRCYJPOSA-N

애플리케이션

Geranylgeranyl pyrophosphate ammonium salt has been used:

in the preparation of 2.5X reaction buffer for Rab GGTase assay
to add to the culture to further drive Hmg2 degradation
as a substrate to carryout in vitro enzymatic assays for the characterization of the prenyltransferases
to reverse the action of lovastatin and also used to examine the potential role of GGPP in the study to assess the effects of exposing the melanoma cell lines in the angiogenesis model as a co-culture to lovastatin in vitro

생화학적/생리학적 작용

Geranylgeranyl pyrophosphate (GGPP) is a major enzyme that participates in the secondary metabolism of chloroplast. GGPP synthase plays a key role in the biosynthesis of terpenoid. Protein geranylgeranylation, mediated by geranylgeranyl pyrophosphate participates in the development of the ventricular chamber. It also serves as a stage-specific signal to modulate the formation of cardiac cytoarchitecture the time of mid-gestation.

Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular weight G proteins, including Ras. Intermediate in terpene biosynthesis.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

픽토그램

GHS02,GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H225,H301 + H311 + H331,H370

예방조치 성명서

P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point (°F)

51.8 °F - closed cup

Flash Point (°C)

11 °C - closed cup

개인 보호 장비

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

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COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Responses of Synechocystis sp. PCC 6803 to heterologous biosynthetic pathways.

Konstantinos Vavitsas et al.

Microbial cell factories, 16(1), 140-140 (2017-08-16)

There are an increasing number of studies regarding genetic manipulation of cyanobacteria to produce commercially interesting compounds. The majority of these works study the expression and optimization of a selected heterologous pathway, largely ignoring the wholeness and complexity of cellular

Frontalin pheromone biosynthesis in the mountain pine beetle, Dendroctonus ponderosae, and the role of isoprenyl diphosphate synthases.

Christopher I Keeling et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(47), 18838-18843 (2013-10-30)

The mountain pine beetle (Dendroctonus ponderosae Hopkins) is the most destructive pest of western North American pine forests. Adult males produce frontalin, an eight-carbon antiaggregation pheromone, via the mevalonate pathway, as part of several pheromones that initiate and modulate the

Isoprenoid biosynthesis in the diatom Haslea ostrearia

Athanasakoglou A, et al.

The New phytologist (2018)

Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury.

Sergi Guixé-Muntet et al.

Journal of hepatology, 66(1), 86-94 (2016-08-23)

The transcription factor Krüppel-like factor 2 (KLF2), inducible by simvastatin, confers endothelial vasoprotection. Considering recent data suggesting activation of autophagy by statins, we aimed to: 1) characterize the relationship between autophagy and KLF2 in the endothelium, 2) assess this relationship

Action of Lovastatin (Mevinolin) on an in vitro model of angiogenesis and its co-culture with malignant melanoma cell lines

Depasquale I and Wheatley D N

Cancer Cell International, 6(1), 9-9 (2006)

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Geranylgeranyl pyrophosphate ammonium salt