E8126
Equilin
synthetic (organic), ≥98% (HPLC), 17β-HSD1 inhibitor, powder
동의어(들):
1,3,5(10),7-Estratetraen-3-ol-17-one, 3-Hydroxy-1,3,5(10),7-estratetraen-17-one, 7-Dehydroestrone
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H20O2
CAS 번호:
Molecular Weight:
268.35
Beilstein:
2624302
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
제품 이름
Equilin,
생물학적 소스
synthetic (organic)
Quality Level
무균
non-sterile
분석
≥98% (HPLC)
양식
powder
기술
inhibition assay: suitable
mp
238-240 °C (lit.)
solubility
chloroform: methanol (1:1): 40 mg/mL, clear, colorless to faintly yellow
배송 상태
ambient
저장 온도
room temp
SMILES string
C[C@]12CC[C@H]3C(=CCc4cc(O)ccc34)[C@@H]1CCC2=O
InChI
1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1
InChI key
WKRLQDKEXYKHJB-HFTRVMKXSA-N
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관련 카테고리
생화학적/생리학적 작용
Equilin is the Mare estrogen and is majorly used in multi-estrogen drugs for hormone replacement therapy. It is synthesized in the microsomes of mare placenta. It mediates estrogen receptor β (ERβ) expression resulting in the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) which favors monocytes adhesion in atherosclerosis. In vitro equilin inhibits 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that catalyzes the conversion of estrone to 17β-estradiol.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Carc. 2 - Lact. - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Equilin
Handbook of Hormones, 582-582 (2016)
Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1, 3, 5, 7-tetraen-17-one (equilin) and NADP+
Sawicki MW, et al.
Proceedings of the National Academy of Sciences of the USA, 96(3), 840-845 (1999)
Equilin and equilenin biosynthesis. Stereochemistry of aromatization of 3-hydroxy-3, 5, 7-androstatrien-17-one by horse placenta
Mitsuteru N and Yoshio O
Journal of Steroid Biochemistry, 26(1), 137-143 (1987)
Fumitake Ito et al.
PloS one, 14(1), e0211462-e0211462 (2019-01-31)
The adhesion of monocytes to endothelial cells, which is mediated by adhesion molecules, plays a crucial role in the onset of atherosclerosis. Conjugated equine estrogen, which is widely used for estrogen-replacement therapy, contains both estrone sulfate and various nonhuman estrogens
C Azoulay
La Revue de medecine interne, 25(11), 806-815 (2004-10-27)
The data concerning post-menopausal hormone replacement therapy (HRT) were recently completely modified. The aim of this review is to present the last studies about post-menopausal HRT and to describe new alternatives to this treatment. In May 2002, the women's health
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