A0737
N-acetylcysteine amide
≥98% (HPLC), lyophilized powder, antioxidant
동의어(들):
(R)- 2-(Acetylamino)-3-mercapto-Propanamide, AD4, N-Acetyl-L-cysteinamide, NACA, acetylcysteinamide
로그인조직 및 계약 가격 보기
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C5H10N2O2S
CAS 번호:
Molecular Weight:
162.21
MDL number:
UNSPSC 코드:
12352209
PubChem Substance ID:
NACRES:
NA.25
제품 이름
N-acetylcysteine amide, ≥98% (HPLC)
Quality Level
분석
≥98% (HPLC)
양식
lyophilized powder
저장 조건
desiccated
색상
white to off-white
solubility
H2O: ≥20 mg/mL
DMSO: >40 mg/mL
저장 온도
2-8°C
SMILES string
CC(=O)N[C@@H](CS)C(N)=O
InChI
1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1
InChI key
UJCHIZDEQZMODR-BYPYZUCNSA-N
관련 카테고리
애플리케이션
N-acetylcysteine amide has been used:
- to protect retinal pigment epithelium (RPE) from oxidative stress
- to show that increased expression of cell adhesion molecule 4 (CADM4) in oligodendrocytes inhibits myelination
- to protect cells from apoptosis induced by shikonin plus erlotinib/gefitinib
- as a component in various culture media
as an antioxidant to reduce oxidative stress in brains of homozygous Drosophila spermine synthase (dSms e/e) mutant flies and melanoma cells.
생화학적/생리학적 작용
N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS.
N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.
기타 정보
This product is hydroscopic and air sensitive.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Intracellular effects of atmospheric-pressure plasmas on melanoma cancer cells
Ishaq M, et al.
Physics of Plasmas, 22(12), 122003-122003 (2015)
Shikonin sensitizes wild-type EGFR NSCLC cells to erlotinib and gefitinib therapy
Li YL, et al.
Molecular Medicine Reports, 18(4), 3882-3890 (2018)
Oxidative stress-mediated NFkappaB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy
Song C, et al.
PLoS ONE, 12(2), e0171940-e0171940 (2017)
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome
Li C, et al.
Nature Communications, 8(1), 1257-1257 (2017)
Axoglial adhesion by cadm4 regulates CNS myelination
Elazar N, et al.
Neuron, 101(2), 224-231 (2019)
문서
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
관련 콘텐츠
일산화질소 (NO) 및 세포 스트레스 연구를 위한 생체 활성 저분자
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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