STAT3 Inhibitor V, Stattic

Name: STAT3 Inhibitor V, Stattic
Brand: MM

STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

동의어(들):

STAT3 Inhibitor V, Stattic, 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

로그인조직 및 계약 가격 보기

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₈H₅NO₄S

CAS 번호:

19983-44-9

Molecular Weight:

211.19

MDL number:

MFCD00173799

UNSPSC 코드:

12352200

NACRES:

NA.77

주요 문서

모든 문서 보기

기술 서비스

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도움 문의

기술 서비스

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도움 문의

Quality Level

100

분석

≥95% (HPLC)

양식

solid

제조업체/상표

Calbiochem^®

저장 조건

OK to freeze
protect from light

색상

pale yellow

solubility

DMSO: 10 mg/mL
ethanol: 5 mg/mL

배송 상태

ambient

저장 온도

2-8°C

SMILES string

[S]1(=O)(=O)c2c(ccc(c2)[N+](=O)[O-])C=C1

InChI

1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

InChI key

ZRRGOUHITGRLBA-UHFFFAOYSA-N

일반 설명

A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr⁷⁰⁵ with little effect towards STAT1 phosphorylation at Tyr⁷⁰¹ (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
STAT3

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.

기타 정보

Schust, J., et al. 2006. Chem. Biol.13, 1235.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

GHS07

신호어

Warning

유해 및 위험 성명서

H302,H315,H319,H335

예방조치 성명서

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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STAT3 Inhibitor V, Stattic