SAB4504327
Anti-phospho-Werner Syndrome Helicase (pSer1141) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
RECQ3, RECQL2, WRN
Sign Into View Organizational & Contract Pricing
Select a Size
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 162 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer1141)
Gene Information
human ... WRN(7486)
General description
Werner syndrome, RecQ helicase-like (WRN) protein belongs to the RecQ family of DNA helicases. It has an adenosine triphosphate (ATP) binding site, one DExH helicase box, one exonuclease domain, and a nuclear localization signal. It is predominantly located in the nucleus. The WRN gene is located on human chromosome 8p12.
Immunogen
The antiserum was produced against synthesized peptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141.
Immunogen Range: 1107-1156
Immunogen Range: 1107-1156
Biochem/physiol Actions
Werner syndrome, RecQ helicase-like (WRN) can interact with DNA polymerase δ (POLD1) and replication protein A (RPA) that are essential for the replication and repair of DNA. It also interacts with Ku protein which participates in double-strand DNA break repair. Mutation of the WRN gene results in Werner syndrome. WRN is a mortal target for cancer cells with microsatellite instability (MSI).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service