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S4760

N-Succinyl-Ala-Ala-Ala-p-nitroanilide

Name: N-Succinyl-Ala-Ala-Ala-<I>p</I>-nitroanilide
Brand: SIGMA

elastase substrate, chromogenic, ≥98% (HPLC), powder

Synonym(s):

N-Succinyl-L-alanyl-L-alanyl-L-alanine 4-nitroanilide, N-Succinyl-tri-L-alanine 4-nitroanilide

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₅N₅O₈

CAS Number:

52299-14-6

Molecular Weight:

451.43

NACRES:

NA.32

PubChem Substance ID:

24899617

UNSPSC Code:

12352204

EC Number:

257-823-5

MDL number:

MFCD00036774

Beilstein/REAXYS Number:

2928351

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Properties

Product Name

N-Succinyl-Ala-Ala-Ala-p-nitroanilide, elastase substrate

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

DMF: 25 mg/mL, clear, colorless to light yellow

storage temp.

2-8°C

SMILES string

C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C19H25N5O8/c1-10(20-15(25)8-9-16(26)27)17(28)21-11(2)18(29)22-12(3)19(30)23-13-4-6-14(7-5-13)24(31)32/h4-7,10-12H,8-9H2,1-3H3,(H,20,25)(H,21,28)(H,22,29)(H,23,30)(H,26,27)/t10-,11-,12-/m0/s1

InChI key

GVUGADOWXGKRAE-SRVKXCTJSA-N

Description

General description

N-Succinyl-Ala-Ala-Ala-p-nitroanilide is a chromogenic substrate for chymotrypsin-like serine protease, pancreatic elastase and serine endopeptidase.

Elastase substrate.

Application

N-Succinyl-Ala-Ala-Ala-p-nitroanilide has been used as a substrate

for screening elastase activity in lyophilized earthworm fibrinolytic enzymes
for quantifying elastase activity in sheep milk
in screening honeybee inhibitors in serine protease inhibition assay

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Protocols

Enzymatic Assay of Elastase (EC 3.4.21.36)

Enzymatic Assay of Elastase (EC 3.4.21.36), a continuous spectrophotometric rate determination.

Articles

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Global Trade Item Number

SKU	GTIN
S4760-5MG	04061832918518
S4760-100MG	04061836928315
S4760-25MG	04061836928353
S4760-500MG	04061836928513