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L9793

LP44

Name: LP44
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₃₈ClN₃OS

CAS Number:

824958-12-5

Molecular Weight:

488.13

NACRES:

NA.77

PubChem Substance ID:

329817675

UNSPSC Code:

12352200

MDL number:

MFCD09971090

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: ≥2 mg/mL

storage temp.

2-8°C

SMILES string

Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2

InChI

1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24;/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31);1H

InChI key

DWGKCWWWKHCVDH-UHFFFAOYSA-N

Description

Application

LP44 has been used as a 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) agonist to study its effects on mitochondria-mediated leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation.

Biochem/physiol Actions

LP44 is a high affinity 5-HT₇ receptor agonist.

LP44 is a high affinity 5-HT₇ receptor agonist. K_i = 0.22 nM. LP44 displays selectivity over 5-HT_1A and 5-HT_2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC₅₀ = 2.56 μM).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

028K4610

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Articles

Serotonin Receptors

We offer many products related to serotonin receptors for your research needs.

Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon.

Lynn Meurs et al.

PloS one, 6(9), e24393-e24393 (2011-09-21)

Schistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shapes the adaptive response, has not been extensively studied. In

The serotonin (5-hydroxytryptamine) 5-HT7 receptor is up-regulated in Onuf's nucleus in rats with chronic spinal cord injury.

Jianshu Ni et al.

BJU international, 123(4), 718-725 (2018-05-22)

To examine the effect of intrathecal (i.t.) serotonin (5-hydroxytryptamine) 5-HT7 agonist administration on voiding function in the urethane-anesthetised rat, and the change in 5-HT7 receptor (5-HT7 R) expression in the lumbosacral cord Onuf's nucleus after spinal cord injury (SCI). In

Evaluation of 5-HT7 Receptor Trafficking on In Vivo and In Vitro Model of Lipopolysaccharide (LPS)-Induced Inflammatory Cell Injury in Rats and LPS-Treated A549 Cells.

Gulsen Ayaz et al.

Biochemical genetics, 55(1), 34-47 (2016-09-03)

This study aimed to investigate the effects of the 5-HT7 receptor agonist (LP44) and antagonist (SB269970) on LPS-induced in vivo tissue damage and cell culture by molecular methods. This study was conducted in two steps. For in vivo studies, 24 female

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Global Trade Item Number

SKU	GTIN
L9793-10MG	04061832072159
L9793-50MG	04061832072166