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Merck

90101

Sigma-Aldrich

Ampliflu™ Red

suitable for fluorescence, ≥98.0% (HPLC)

Synonym(s):

10-Acetyl-3,7-dihydroxyphenoxazine

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About This Item

Empirical Formula (Hill Notation):
C14H11NO4
CAS Number:
119171-73-2
Molecular Weight:
257.24
MDL number:
MFCD00467861
UNSPSC Code:
12352108
PubChem Substance ID:
329769846
NACRES:
NA.32

Key Documents

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Quality Level

100

Assay

≥98.0% (HPLC)

form

powder

mol wt

257.24 g/mol

concentration

90-100 % (w/w) (Ampliflu Red)

color

slightly brown-red
 white to slightly brown

solubility

water: slightly soluble at 20 °C

fluorescence

λex 571 nm; λem 585 nm in DMSO

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

CC(=O)N1c2ccc(O)cc2Oc3cc(O)ccc13

InChI

1S/C14H11NO4/c1-8(16)15-11-4-2-9(17)6-13(11)19-14-7-10(18)3-5-12(14)15/h2-7,17-18H,1H3

InChI key

PKYCWFICOKSIHZ-UHFFFAOYSA-N

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Application

Ampliflu™ Red has been used to study mitochondrial abnormalities and oxidative stress related to Parkinson’s Disease. Ampliflu™ Red assay was suitable as an alternative indicator assay for detecting the inhibition of hTPO (human thyroid peroxidase) activity. Phospholipase D, an essential cellular process ingredient, used Ampliflu™ Red (10-Acetyl-3,7-dihydroxyphenoxazine) to determine its activity.Ampliflu™ Red is used for the following applications:
  • Quantification of inflammatory mediators
  • Determination of free and esterified cholesterol contents
  • Evaluation of compounds as substrates for GABA-AT compounds

Legal Information

Ampliflu is a trademark of Sigma-Aldrich Co. LLC

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1284
BCCF8219
BCCC6933
BCCB8863
BCBZ9998

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Thais Soprani Ayala et al.
Scientific reports, 9(1), 11447-11447 (2019-08-09)
Macrophages may be a crucial aspect of diabetic complications associated with the inflammatory response. In this study, we examined how hyperglycaemia, a common aspect of diabetes, modulates bone marrow-derived macrophages (BMDMs) under an inflammatory stimulus. To perform this study, BMDMs
Kazuo Sugiyama et al.
PloS one, 9(4), e94460-e94460 (2014-04-11)
Most of experiments for HCV infection have been done using lytic infection systems, in which HCV-infected cells inevitably die. Here, to elucidate metabolic alteration in HCV-infected cells in a more stable condition, we established an HCV-persistently-infected cell line, designated as
Dustin D Hawker et al.
Bioorganic & medicinal chemistry, 20(19), 5763-5773 (2012-09-05)
Two principal neurotransmitters are involved in the regulation of mammalian neuronal activity, namely, γ-aminobutyric acid (GABA), an inhibitory neurotransmitter, and L-glutamic acid, an excitatory neurotransmitter. Low GABA levels in the brain have been implicated in epilepsy and several other neurological
Anne H van der Spek et al.
Endocrine connections, 6(8), 731-740 (2017-11-05)
Innate immune cells have recently been identified as novel thyroid hormone (TH) target cells in which intracellular TH levels appear to play an important functional role. The possible involvement of TH receptor alpha (TRα), which is the predominant TR in
Houjuan Zhu et al.
ACS nano, 11(9), 8998-9009 (2017-08-26)
Development of optical nanotheranostics for the capability of photodynamic therapy (PDT) provides opportunities for advanced cancer therapy. However, most nanotheranostic systems fail to regulate their generation levels of reactive oxygen species (ROS) according to the disease microenvironment, which can potentially
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