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33120-M

N,N-Dimethylformamide

puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.8% (GC)

Synonym(s):

DMF, NSC 5356

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About This Item

Linear Formula:
HCON(CH3)2
CAS Number:
68-12-2
Molecular Weight:
73.09
UNSPSC Code:
12352111
NACRES:
NA.21
PubChem Substance ID:
329754458
EC Number:
200-679-5
Beilstein/REAXYS Number:
605365
MDL number:
MFCD00003284
Assay:
≥99.8% (GC)
Technique(s):
cell culture | plant: suitable
Bp:
152-154 °C, 153 °C (lit.)
Vapor pressure:
2.7 mmHg ( 20 °C)
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Quality Level

100

agency

reag. Ph. Eur.

vapor density

2.5 (vs air)

vapor pressure

2.7 mmHg ( 20 °C)

grade

ACS reagent, puriss. p.a.

assay

≥99.8% (GC)

form

liquid

autoignition temp.

833 °F

expl. lim.

15.2 %

technique(s)

cell culture | plant: suitable

impurities

≤0.001% non-volatile matter, ≤0.003% free acid (as CH3COOH), ≤0.005% free alkali (as NH3), ≤0.1% water (Karl Fischer)

color

APHA: ≤15

refractive index

n20/D 1.4290-1.4310, n20/D 1.430 (lit.)

pH

6.7

bp

152-154 °C, 153 °C (lit.)

mp

−61 °C (lit.)

density

0.948-0.950 g/mL at 20 °C, 0.944 g/mL (lit.)

SMILES string

[H]C(=O)N(C)C

cation traces

Al: ≤0.5 mg/kg, B: ≤0.02 mg/kg, Ba: ≤0.1 mg/kg, Bi: ≤0.1 mg/kg, Ca: ≤0.5 mg/kg, Cd: ≤0.05 mg/kg, Co: ≤0.02 mg/kg, Cr: ≤0.02 mg/kg, Cu: ≤0.02 mg/kg, Fe: ≤0.1 mg/kg, K: ≤0.5 mg/kg, Li: ≥0.1 mg/kg, Mg: ≤0.1 mg/kg, Mn: ≤0.02 mg/kg, Mo: ≤0.1 mg/kg, Na: ≤1 mg/kg, Ni: ≤0.02 mg/kg, Pb: ≤0.1 mg/kg, Sn: ≤0.1 mg/kg, Sr: ≤0.1 mg/kg, Zn: ≤0.1 mg/kg

InChI

1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

InChI key

ZMXDDKWLCZADIW-UHFFFAOYSA-N

General description

N,N-Dimethylformamide (DMF) is commonly employed as a solvent for various organic reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues. It is widely employed reagent in organic synthesis. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups.

Application

Solvent for many hydrophobic organic compounds.
N,N-Dimethylformamide (DMF) may be employed as a solvent in the following studies:
  • Extraction of chlorophyll containing pigments from the intact tissues of cotyledons of Cucumis sativus.
  • Isolation of chlorophyll a from the cell cultures of unicellular marine algae.4
  • As reducing agent and solvent for the preparation of Au@Ag core-shell nanocrystals.

Packaging

2.5 L also available in PE-bottles

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

136.4 °F - closed cup

flash_point_c

58 °C - closed cup

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W P Inskeep et al.
Plant physiology, 77(2), 483-485 (1985-02-01)
We found inconsistencies in the commonly used data for chlorophyll analysis in 80% acetone. Recently developed extinction coefficients for chlorophyll b in N,N-dimethylformamide (DMF) based on values from 80% acetone are low as a result of these inconsistencies. We determined
Shengtao Ding et al.
Angewandte Chemie (International ed. in English), 51(37), 9226-9237 (2012-08-30)
Often used as a common solvent for chemical reations and utilized widely in industry as a reagent, N,N-dimethylformamide (DMF) has played an important role in organic synthesis for a long time. Numerous highly useful articles and reviews discussing its utilizations