SAB5500055
Anti-CD25 antibody, Rabbit monoclonal
recombinant, expressed in proprietary host, clone SP176, affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP176, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
rat, mouse
technique(s)
immunohistochemistry: 1:100
western blot: 1:200
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... IL2RA(3559)
General description
IL2RA (interleukin 2 receptor subunit α) gene codes for interleukin-2 receptor α-chain CD25. CD25 is expressed on activated T-cells. The activated T-cells liberate this molecule in the form of a soluble variant (referred to as soluble IL-2 receptor; sIL-2R) from the cell membrane into the circulation. The CD25 gene is located on human chromosome 10p15. The gene spans a length of 48kb with eight exons.
Interleukin-2 receptor subunit alpha, also known as CD25, is a type I transmembrane protein and the alpha chain of the IL-2 receptor. CD25 and CD122 form a heterodimer to act as a high-affinity receptor for IL-2. CD25 is expressed on activated T cells, activated B cells, some thymocytes, myeloid precursors, oligodendrocytes, and most B cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes.
Immunogen
Synthetic peptide derived from the C-terminus of human CD25 protein.
Biochem/physiol Actions
Interleukin-2 (IL-2) is a cytokine that is essential in modulating activation, proliferation, and survival of several T-cell subsets. IL2RA gene has been associated with susceptibility to multiple sclerosis (MS).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Find documentation for the products that you have recently purchased in the Document Library.
Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis.
Buhelt S, et al.
Cytokine, 93, 15-25 (2017)
Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes?
Bharwani KD, et al.
Mediators of Inflammation, 2017, 2764261-2764261 (2017)
Toward further mapping of the association between the IL2RA locus and type 1 diabetes.
Qu H Q, et al.
Diabetes, 56(4), 1174-1176 (2007)
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