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KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

Synonym(s):

Amination Screening Kit, Buchwald-Hartwig Amination

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About This Item

NACRES:
NA.22
UNSPSC Code:
12161503
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product line

KitAlysis™

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Cross Couplings, reagent type: catalyst
core: palladium

storage temp.

room temp

General description

The KitAlysis™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains



  • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
  • 2 bases (NaOt-Bu and Cs2CO3)
  • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
  • 2 substrate reaction vials with stir bars
  • 1 internal standard
  • 4 reaction block replacement films
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists
  • Easily run 24-microscale reaction in parallel
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit Components Only

Product No.
Description
  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Kit Components Also Available Separately

Product No.
Description
SDS & Pricing
  • 900634
    N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mL
    SDS
  • 900640
    1,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mL
    SDS
  • 702706
    Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mL
    SDS
  • 747130
    Josiphos SL-J009-1 Pd G3 5 µmol
    SDS
  • 753009
    SPhos Pd G2 5 µmol
    SDS
  • 753246
    RuPhos Pd G2 5 µmol
    SDS
  • 756482
    P(t-Bu)3 Pd G2 5 µmol
    SDS
See All (15)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3

target_organs

Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

flash_point_f

-4.0 °F - closed cup

flash_point_c

-20 °C - closed cup

wgk

WGK 3

supp_hazards

EUH014,EUH019

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Certificates of Analysis (COA)

Lot/Batch Number

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Protocols

Catalyst Screening & TLC-MS for Reaction Analysis

Catalyst screening kits, KitAlysis™, and TLC-MS analysis enable high-throughput synthesis and analysis for efficient reactions.

Two solvents (Dioxane, DMAc), Strong Base (NaOt-Bu) Step-by-Step Guide for Buchwald-Hartwig Amination Reaction Screening Kit

Protocol for the KitAlysis™ Buchwald-Hartwig Amination Reaction Screening Kit

Two solvents (Dioxane, DMAc), weak base (Cs2CO3) Step-by-Step Guide for Buchwald-Hartwig Amination Screening Kit

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

View All Protocols

Articles

KitAlysis™ C-N (Buchwald-Hartwig) High-Throughput Screening Kit

All contents in the foil bag are weighed, plated, packed, and sealed in a glove box under nitrogen.

High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al. et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in
View All Related Papers

Global Trade Item Number

SKUGTIN
KITALYSIS-CN-1KT04061833945223