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Cancer Research

Cancer Research

Due to disease complexity, Cancer Research is a multidisciplinary field that spans basic, translational, and clinical research. Insights into the causes and mechanisms of cancer development and progression have yielded new methods for cancer prevention, detection, and treatment.

This Scientific hub for Cancer Research will help you to find info on Merck’s Products and Solutions, Technical Resources (protocols, application notes and papers), Webinars on Cancer and Immuno-Oncology, New Brochures and Testimonial Stories from the lab.

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Products and Solutions


Technical Resources and Protocols


Additional Resources

NEW - Using Multiplex Bioassays to Profile Biomarkers of Precursors to Pancreatic Cancer
See how using multiplex immunoassays to profile biomarkers is a versatile research tool in potential early and reliable detection of pancreatic cancer precursors.

NEW - Organoids in Immuno-Oncology
This webinar explaines the importance of 3D cell culture models such as organoids in understanding cancer biology and their role in studying the interactions between cancer cells and the immune system. Additionally, it explores the potential applications and benefits of organoids in Immuno-Oncology and anti-cancer therapeutics.

Famous Cancers
Using the fascinating world of celebrities to introduce the immunohistochemical grid approach to cancer disease states.

Liver Cancer and Immunohistochemistry
In this webinar we will discuss the markers used in detecting liver carcinoma as well as other antibody grids that can be run to aid in the identification of primary liver carcinoma.

Soft Tissue Cancer and Immunohistochemistry
Soft tissue tumors are a broad group of neoplasms that involve the connective tissue of the body. Each year, over 13,000 people in the US are diagnosed with soft tissue sarcomas and over 5,000 people succumb to the malignancy. Because soft tissue sarcomas are very ambiguous and amorphous, many time sarcomas are classified as an uncertain type. Advances in immunohistochemistry as well as the utility of novel markers such as TFE3, TLE1, MyoD1, and MUC4 have aided pathologists in classifying these soft tissue tumors. This discussion will cover the key facts and statistics about soft tissue tumors and what role IHC plays in these difficult diagnoses.

Characterizing the tumor microbiome using 5R-PLEX technology
This webcast will highlight key findings related to the characterization of the tumor microbiome in various cancers and give a special focus to technical challenges in the study of low biomass niches and the different approaches for addressing them. It will also describe the 5R bacterial 16S-Seq method (5R-PLEX method) that not only enables the characterization of the microbiome in tumors that are preserved in paraffin blocks (FFPE), but also increases the coverage and resolution of bacterial profiling as compared to other standard 16S-Seq methods.

Quantitative Lipidomics
Key concepts of lipidomics and description of novel ‘shotgun’ workflows for quantitative lipidome analysis and detailed structural characterization, giving insights into the role of lipid metabolism in colorectal cancer biology.

Standardization of Metabolomics - IROA TruQuant IQQ
TruQuant IQQ is a high-quality quantitation system for making simultaneous accurate biological measurements on several hundred biochemicals in small quantities of biological samples.

Metabolite Assay Kits
An introduction to our easy to use Metabolism Assay Kits that accelerate your research, including fast fatty acids and cholesterols sample prep as well as the D2HG Kit for cancer research.

Immune Responses Associated with Losartan-TKI Combination Immunotherapy in Dogs with Metastatic Osteosarcoma
In this Webinar, Dr Regan will present data regarding novel immunotherapy in dogs with spontaneous metastatic osteosarcoma. This work led to clinical trials in paediatric and young adult humans with osteosarcoma.

Predicting through Multiplexing: Immune checkpoint inhibition benefits in advanced NSCLC
The dynamics of tumour and immune responses associated with immune checkpoint blockade are unique and complex. Despite the initial successes of immunotherapy, a low objective response rate due to resistance is still the main challenge in solid tumours, particularly advanced-stage lung cancer. One manifestation of tumour-immune dynamics is a release of soluble immune checkpoints and regulators to the surrounding microenvironment and circulation, the biological role of which has yet to be revealed. However, many studies highlight the clinical significance of soluble molecules such as sPD-1 and sLAG3.

Functional Genomics Screening
In this webinar, you will discover an overview of the broad range of available functional genomic screening technologies, including traditional shRNA, ORF, CRISPR KO, to CRISPRi, CRISPRa and single cell analysis.

CRISPR Tools and Technologies for Accelerating Research
We will describe some of the uses of the CRISPR/Cas system that allows researchers to uncover, enrich, and discover new biomarkers and pathways important for diagnostic applications.

 

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