R7017
Resazurin sodium salt
powder, BioReagent
Synonyme(s) :
7-Hydroxy-3H-phenoxazin-3-one-10-oxide sodium salt
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A propos de cet article
Formule empirique (notation de Hill) :
C12H6NNaO4
Numéro CAS:
Poids moléculaire :
251.17
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
263-718-5
Beilstein/REAXYS Number:
3794971
MDL number:
Service technique
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BioReagent
Quality Level
form
powder
composition
Dye content, ~80%
pH
3.8-6.5, orange to violet
solubility
H2O: soluble
λmax
600 nm
SMILES string
[Na+].[O-]c1ccc2c(OC3=CC(=O)C=CC3=[N+]2[O-])c1
InChI
1S/C12H7NO4.Na/c14-7-1-3-9-11(5-7)17-12-6-8(15)2-4-10(12)13(9)16;/h1-6,14H;/q;+1/p-1
InChI key
IVGPGQSSDLDOLH-UHFFFAOYSA-M
Application
Resazurin sodium salt has been used in viability assay:
- to measure cell viability of A. fumigatus
- to assess cell proliferation
- to determine A. fumigatus viability in high-throughput screenings of microbial natural extracts
For the measurement of metabolic activity and proliferation of living cells. The bioreduction of the dye reduces the amount of the oxidized form (blue) and concomitantly increases the fluorescent intermediate (red).
Biochem/physiol Actions
Resazurin is a blue, non-fluorescent dye originally used to test milk/biological fluids for bacterial and yeast contamination. It is also useful in sperm viability and semen quality test. Resazurin is applicable in cytotoxicity determination.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
O Brien J, et al.
European Journal of Biochemistry, 267(17), 5421-5426 (2000)
Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb
Chao DT, et al.
Journal of Cancer Research and Clinical Oncology, 139, 315?325-315?325 (2012)
Sugandha Bhatia et al.
Journal of clinical medicine, 8(6) (2019-06-27)
Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have delineated epithelial and mesenchymal subpopulations existing within the PMC42-LA breast cancer cell line by their EpCAM expression. These
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| R7017-1G | 04061835569335 |
| R7017-5G | 04061836695965 |