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D7910

3,4-Dichloroisocoumarin

Name: 3,4-Dichloroisocoumarin
Brand: SIGMA

≥98% (TLC), Serine protease inhibitor, powder

Synonyme(s) :

3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one

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A propos de cet article

Formule empirique (notation de Hill) :

C₉H₄Cl₂O₂

Numéro CAS:

51050-59-0

Poids moléculaire :

215.03

NACRES:

NA.77

PubChem Substance ID:

24278386

UNSPSC Code:

12352202

MDL number:

MFCD00036960

Beilstein/REAXYS Number:

6802625

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Propriétés

Nom du produit

3,4-Dichloroisocoumarin, serine protease inhibitor

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)c2ccccc2C(=O)O1

InChI

1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H

InChI key

SUGXUUGGLDCZKB-UHFFFAOYSA-N

Description

General description

Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

Application

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.

Preparation Note

Half-life = 20 min at pH 7.5.

Other Notes

Effective concentration 5-100 μM.

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pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number

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Serine protease inhibitors block invasion of host cells by Toxoplasma gondii.

V Conseil et al.

Antimicrobial agents and chemotherapy, 43(6), 1358-1361 (1999-05-29)

We investigated the effect of protease inhibitors on the asexual development of the protozoan parasite Toxoplasma gondii. Among the inhibitors tested only two irreversible serine protease inhibitors, 3,4-dichloroisocoumarin and 4-(2-aminoethyl)-benzenesulfonyl fluoride, clearly prevented invasion of the host cells by specifically

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor.

A Weihofen et al.

The Journal of biological chemistry, 275(40), 30951-30956 (2000-08-02)

Signal peptides of secretory and membrane proteins are generated by proteolytic processing of precursor proteins after insertion into the endoplasmic reticulum membrane. Liberated signal peptides can be further processed, and the resulting N-terminal fragments are released toward the cytosol, where

Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill.

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Particle and fibre toxicology, 15(1), 34-34 (2018-08-12)

There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a

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Numéro d'article de commerce international

Référence	GTIN
D7910-10MG	04061833270547
D7910-25MG	04061833270554
D7910-5MG	04061833270561