D4434
Dichloromethylenediphosphonic acid disodium salt
osteoclastic activity inhibitor, powder
Synonyme(s) :
Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP
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A propos de cet article
Formule linéaire :
CH2O6Cl2Na2P2
Numéro CAS:
Poids moléculaire :
288.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
245-078-9
MDL number:
Form:
powder
Quality level:
Service technique
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Laissez-nous vous aiderNom du produit
Dichloromethylenediphosphonic acid disodium salt,
form
powder
Quality Level
solubility
water: 49.00-51.00 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O
InChI
1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
InChI key
HJKBJIYDJLVSAO-UHFFFAOYSA-L
Gene Information
rat ... Man2a1(25478), Si(497756)
Biochem/physiol Actions
Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Fabricio Montalvao et al.
The Journal of clinical investigation, 123(12), 5098-5103 (2013-11-02)
Anti-CD20 Ab therapy has proven successful for treating B cell malignancies and a number of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell depletion is not fully understood. In particular, the anatomical location, the type
A Lipton
Cancer, 80(8 Suppl), 1668-1673 (1997-11-15)
The skeleton is a common site of breast carcinoma metastasis; 75% of patients with breast carcinoma demonstrate bone metastases at autopsy. The lytic destruction of bone in these patients is due to excessive osteoclastic activity. By reducing osteoclastic activity, bisphosphonates
H A Fleisch
Annals of medicine, 29(1), 55-62 (1997-02-01)
The bisphosphonates are synthetic compounds characterized by a P-C-P bond. They have a strong affinity to calcium phosphates and hence to bone mineral. In vitro they inhibit both formation and dissolution of the latter. Many of the bisphosphonates inhibit bone
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| D4434-1G | 04061833564424 |