B4750
Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride
trypsin substrate
Synonyme(s) :
BANA, Nα-Benzoyl-DL-arginine-2-naphthylamide hydrochloride
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A propos de cet article
Formule empirique (notation de Hill) :
C23H25N5O2 · HCl
Numéro CAS:
Poids moléculaire :
439.94
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
213-015-4
Beilstein/REAXYS Number:
3823291
MDL number:
Service technique
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assay
≥98% (TLC)
form
powder
solubility
DMF: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
Cl[H].NC(=N)NCCCC(NC(=O)c1ccccc1)C(=O)Nc2ccc3ccccc3c2
InChI
1S/C23H25N5O2.ClH/c24-23(25)26-14-6-11-20(28-21(29)17-8-2-1-3-9-17)22(30)27-19-13-12-16-7-4-5-10-18(16)15-19;/h1-5,7-10,12-13,15,20H,6,11,14H2,(H,27,30)(H,28,29)(H4,24,25,26);1H
InChI key
BNGRKDJZQIGWQF-UHFFFAOYSA-N
General description
A chromogenic substrate for trypsin.
Application
Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride has been used as a substrate in the BANA test to evaluate the inhibitory activity of stefin. It has also been used as a substrate for the determination of Ki values of inhibitors toward trypsin.
Biochem/physiol Actions
Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride (BANA) helps to determine the activities of cathepsin B and papain. BANA test is also useful in identifying the number of periodontal sites with periodontal pathogens. Presence of volatile sulfur compounds (VSCs), synthesized by oral bacteria in dental plaque or tongue coating can be colorimetrically confirmed by their ability to hydrolyze N-benzoyl-DL-arginine-2-naphthylamide.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenu apparenté
Marie-Hélène Weech et al.
Journal of experimental botany, 59(9), 2437-2448 (2008-05-20)
Arabidopsis thaliana (L.) Heynh. genotypes limited in their ability to mount either octadecanoid-dependent induced resistance (IR(-)) or systemic acquired resistance (SAR(-)) were used to characterize the roles of these pathways in plant-herbivore interactions. Molecular and biochemical markers of IR were
SAR studies of some acetophenone phenylhydrazone based pyrazole derivatives as anticathepsin agents.
Neera Raghav et al.
Bioorganic chemistry, 75, 38-49 (2017-09-16)
Cathepsins have emerged as promising molecular targets in a number of diseases such as Alzeimer's, inflammation and cancer. Elevated cathepsin's levels and decreased cellular inhibitor concentrations have emphasized the search for novel inhibitors of cathepsins. The present work is focused
Kunitz-type protease inhibitors group B from Solanum palustre
Speransky A S, et al.
Biotechnology Journal, 2(11), 1417-1424 (2007)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| B4750-1G | 04061833433447 |
| B4750-500MG | 04061832921334 |
| B4750-5G | 04061832921341 |