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A8185

Ala-Gln

Name: Ala-Gln
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture

Synonyme(s) :

Alanyl-glutamine, Glutamine-S

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A propos de cet article

Formule empirique (notation de Hill) :

C₈H₁₅N₃O₄

Numéro CAS:

39537-23-0

Poids moléculaire :

217.22

UNSPSC Code:

12352209

PubChem Substance ID:

24891211

NACRES:

NA.75

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Propriétés

product line

BioReagent

Quality Level

300

assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

color

white to off-white

storage temp.

room temp

SMILES string

NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

InChI

1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1

InChI key

HJCMDXDYPOUFDY-WHFBIAKZSA-N

Description

Application

Ala-Gln has been used:

as a supplement in NeuralQ^™ medium
as a component in growth medium and incubation medium (IM) for retinal cell lines
for experimental treatment of retinal cell lines respectively

Biochem/physiol Actions

Alanyl-glutamine (Ala-Gln) is a dipeptide that is used as a substitute for glutamine in mammalian cell culture media, because of the instability of glutamine in solution and the formation of ammonia as a breakdown product of glutamine in solution, which can have deleterious effects on cells in culture. Ala-Glu is stable to heat sterilization and is less ammonia genic than glutamine, which contributes to its advantages as a media component. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro.

Analysis Note

This product is cell culture tested (0.5 mg/ml) and insect cell culture tested (0.2 mg/ml). It is appropriate for use in cell culture and insect cell culture applications at 2-10 mM.

Legal Information

NeuralQ is a trademark of GlobalStem

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Classe de stockage

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Protocoles

Induced Pluripotent Stem Cell Reprogramming Protocols

Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.

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Contenu apparenté

Product Information Sheet - A8185

Effects of oral supplementation with glutamine and alanyl-glutamine on glutamine, glutamate, and glutathione status in trained rats and subjected to long-duration exercise.

Vinicius Fernandes Cruzat et al.

Nutrition (Burbank, Los Angeles County, Calif.), 25(4), 428-435 (2008-12-06)

We investigated the effect of supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine, both in the free form, on the plasma and tissue concentrations of glutamine, glutamate, and glutathione (GSH) in rats subjected to long-duration

A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics

Alterman JF, et al.

Bio-protocol, 7(16) (2017)

The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium

Christie A, et al.

Biotechnology and Bioengineering, 64(3), 298-309 (1999)

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Numéro d'article de commerce international

Référence	GTIN
A8185-1KG	04061833391273
A8185-100G	04061833391266
A8185-5G	04061835568093