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K4000

Kanamycine sulfate from Streptomyces kanamyceticus

Animal Component-free

Synonyme(s) :

Kanamycine sulfate salt, Kanamycine A

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A propos de cet article

Formule empirique (notation de Hill) :
C18H36N4O11 · H2O4S
Numéro CAS:
25389-94-0
Poids moléculaire :
582.58
NACRES:
NA.76
PubChem Substance ID:
24896236
UNSPSC Code:
51281654
EC Number:
246-933-9
MDL number:
MFCD00070253
Service technique
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biological source

Streptomyces kanamyceticus

Quality Level

200

form

powder

potency

≥750 μg per mg (dry basis)

color

white to off-white

solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma

mode of action

protein synthesis | interferes

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

General description

Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus.

Application

Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used:
  • in the research of bacterial antibiotic resistance
  • in the research on the effect of different antibiotics on bud regeneration

Biochem/physiol Actions

Mode d'action : Ce produit agit en se fixant à la sous-unité ribosomale 70S, ce qui inhibe la translocation et provoque des erreurs de codage.

Mode de résistance : les enzymes modifiant les aminoglycosides (dont l'acétyltransférase, la phosphotransférase et la nucléotidyltransférase) peuvent modifier cet antibiotique, l'empêchant alors d'interagir avec les ribosomes.

Spectre antimicrobien : Le sulfate de kanamycine est efficace sur les bactéries à Gram négatif, les bactéries à Gram positif et les mycoplasmes.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Preparation Note

Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible
Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Other Notes

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SLBB0945V
115K0077
078K0100
127K0058
057K0069

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Daniel Teupser et al.
Arteriosclerosis, thrombosis, and vascular biology, 29(5), 678-683 (2009-03-03)
We have previously identified a quantitative trait locus (QTL) for atherosclerosis susceptibility on proximal chromosome 10 (Chr10) (Ath11) in independent crosses of FVB and C57BL/6 (B6) mice on the apolipoprotein E (ApoE-/-) and LDL receptor (LDLR-/-) deficient backgrounds. The aims
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Numéro d'article de commerce international

RéférenceGTIN
K4000-25G04061833943724
K4000-5G04061833944585
K4000-1G04061833943717
K4000-50G04061833944578