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1.06447

Citrate trisodique dihydraté

EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP, ACS, E 331

Synonyme(s) :

Citrate de sodium tribasique dihydrate, Acide citrique trisodium salt dihydrate, Citrate trisodique dihydrate

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A propos de cet article

Formule linéaire :
HOC(COONa)(CH2COONa)2 · 2H2O
Numéro CAS:
6132-04-3
Poids moléculaire :
294.10
UNSPSC Code:
12352107
EC Index Number:
200-675-3
E Number:
E331
MDL number:
MFCD00150031
Beilstein/REAXYS Number:
6104939
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Quality Level

500

agency

BP, ChP, JP, Ph. Eur., USP, suitable for SM 4500 - NH3

product line

EMPROVE® EXPERT

form

solid

feature

RNase and DNase free

impurities

endotoxins, low

pH

7.5-9.0 (25 °C, 50 g/L in H2O)

pKa 

(1) 3.1, (2) 4.8, (3) 6.4

mp

150 °C (anhydrous substance), >300 °C (lit.)

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

2-30°C

SMILES string

O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3

InChI key

NLJMYIDDQXHKNR-UHFFFAOYSA-K

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

tri-Sodium citrate dihydrate is typically used as a citrate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Contenu apparenté

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This page is intended to make it easier to find the consumables you need based on the analytical method you’re using. Methods included on this page come from the EPA, Standard Methods and ASTM.

Formulation

Learn more on mAb subcutaneous or intravenous formulation, and the relevant associated products, including excipients.

Numéro d'article de commerce international

RéférenceGTIN
106447100004022536076928
106447500004022536076942
106447000104027269279790
106447902904022536940328