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A propos de cet article
Formule empirique (notation de Hill) :
C29H56NO9P
Numéro CAS:
Poids moléculaire :
593.73
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Service technique
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Laissez-nous vous aiderNom du produit
POVPC, Avanti Research™ - A Croda Brand 870606P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (870606P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 870606P
lipid type
phosphoglycerides
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC([H])=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O
InChI
1S/C29H56NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(32)36-25-27(39-29(33)21-18-19-23-31)26-38-40(34,35)37-24-22-30(2,3)4/h23,27H,5-22,24-26H2,1-4H3/t27-/m1/s1
InChI key
RKIDALSACBQVTN-HHHXNRCGSA-N
General description
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) is a derivative of oxidized Low density lipoprotein (oxLDL), a proinflammatory lipid present in atherosclerotic lesions.
Application
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) has been used:
- to study its effects on endothelial function and vasodilation
- as a ligand for LRP6 in bone marrow mesenchymal stromal cells (MSCs)
- as a oxidized lipid to study if membrane status at different degrees of lipid peroxidation is involved in oxidative stress tolerance
Biochem/physiol Actions
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC) affects endothelial function by hindering activity of endothelial nitric oxide synthase and stimulating endothelial cell apoptosis. It is implicated in the development of atherosclerosis and it may be used as a potent therapeutic for atherosclerosis.
Packaging
5 mL Clear Glass Sealed Ampule (870606P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Classe de stockage
11 - Combustible Solids
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Clinically relevant radioresistant cells exhibit resistance to H2O2 by decreasing internal H2O2 and lipid peroxidation
Tomita K, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 40(9), 1010428318799250-1010428318799250 (2018)
Oxidized phospholipids are ligands for LRP6
Wang L, et al.
Bone research, 6(1), 22-22 (2018)
Diana M Stafforini et al.
Free radical biology & medicine, 59, 100-107 (2012-06-05)
This article presents a radiometric assay to determine the enzymatic activity of platelet-activating factor (PAF) acetylhydrolase (PAF-AH), also known as lipoprotein-associated phospholipase A2 and phospholipase A2 group 7A. The method is based on the release of radioactively labeled acetate from
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 870606P-1MG | 04061835353811 |