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A propos de cet article
Formule empirique (notation de Hill) :
C34H69NO3
Numéro CAS:
Poids moléculaire :
539.92
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Service technique
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Laissez-nous vous aiderNom du produit
C16 Dihydroceramide (d18:0/16:0), Avanti Research™ - A Croda Brand 860634P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860634P-10mg), pkg of 1 × 5 mg (860634P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860634P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C34H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32-33,36-37H,3-31H2,1-2H3,(H,35,38)/t32-,33+/m0/s1
InChI key
GCGTXOVNNFGTPQ-JHOUSYSJSA-N
Application
C16 Dihydroceramide (d18:0/16:0) is suitable for use to study the potential relevance of the changes observed in the sphingolipid composition of autophagosomes and autolysosomes in tetrahydrocannabinol (THC) treated cells or to destabilize biological membranes.
Biochem/physiol Actions
Dihydroceramide acts as a precursor for ceramide synthesis. It has an ability to induce autophagy in the perinuclear region. Dihydroceramide affects autophagic flux and enhances the formation lipid droplets. Accumulation of C16-dihydroceramides might lead to liver injury.
Packaging
5 mL Amber Glass Screw Cap Vial (860634P-10mg)
5 mL Amber Glass Screw Cap Vial (860634P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Classe de stockage
11 - Combustible Solids
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Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
Hernandez-Tiedra S, et al.
Autophagy, 12(11), 2213-2229 (2016)
Md Abdullah Al Sazzad et al.
Langmuir : the ACS journal of surfaces and colloids, 32(23), 5973-5980 (2016-05-25)
To better understand the interactions of saturated ceramides with unsaturated glycerophospholipids in bilayer membranes, we measured how palmitoyl ceramide (PCer) and dihydroceramide (dihydro-PCer, lacking the trans 4 double bond of the sphingoid base of ceramide) can interact with phosphatidylcholines (PCs)
Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model
Lee Ah young, et al.
Biochemical and biophysical research communications, 494(3-4), 460-469 (2017)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 860634P-5MG | 04061835318810 |