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860549P

Avanti

C24:1 Glucosyl(β) Ceramide (d18:1/24:1(15Z))

Avanti Research™ - A Croda Brand

Synonyme(s) :

D-glucosyl-β-1,1′-N-nervonoyl-D-erythro-sphingosine

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A propos de cet article

Formule empirique (notation de Hill) :
C48H91NO8
Numéro CAS:
887907-50-8
Poids moléculaire :
810.24
MDL number:
MFCD22416611
UNSPSC Code:
12352211
NACRES:
NA.25
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Nom du produit

C24:1 Glucosyl(β) Ceramide (d18:1/24:1(15Z)), Avanti Research™ - A Croda Brand 860549P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (860549P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860549P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O

InChI

1S/C48H91NO8/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(40-56-48-47(55)46(54)45(53)43(39-50)57-48)42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h17-18,35,37,41-43,45-48,50-51,53-55H,3-16,19-34,36,38-40H2,1-2H3,(H,49,52)/

InChI key

WBOZIXHPUPAOIA-JZZPSRGZSA-N

General description

β-Glucosylceramides or glucocerebrosides (GlcCers) are synthesized from the glycosphingolipids by β-GlcCer synthase. They are synthesized in Golgi and endoplasmic reticulum and localized in the cytosolic side of cell membrane. GlcCers are omnipresent.

Application

C24:1 Glucosyl(β) Ceramide (d18:1/24:1(15Z)) may be used:
  • as a standard hexosylceramide for hydrophilic interaction chromatography-based liquid chromatography mass spectroscopy
  • to test its nuclear factor of activated T-cells (NFAT) activation
  • in human natural killer T (NKT) cell potency assays

Biochem/physiol Actions

β-Glucosylceramides (β-GlcCer) levels are elevated inlevels in Gaucher′s disease, due to the deficiency of β-glucosidase. β-GlcCer participates in the inflammatory and acquired immune responses by binding mincle on myeloid cells and has immunostimulatory activity.

Packaging

5 mL Amber Glass Screw Cap Vial (860549P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Classe de stockage

11 - Combustible Solids

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Consulter la Bibliothèque de documents

3-O-sulfo-beta-d-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5
Phongsisay V, et al.
Molecular Immunology, 63(2), 595-599 (2015)
Potent neutralizing anti-CD1d antibody reduces lung cytokine release in primate asthma model
Nambiar J, et al.
MAbs, 7(3), 638-650 (2015)
Intracellular metabolite beta-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity
Nagata M, et al.
Proceedings of the National Academy of Sciences of the USA, 114(16), E3285-E3294 (2017)
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Numéro d'article de commerce international

RéférenceGTIN
860549P-5MG04061835318100