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840033P

Avanti

14:0 PS

Avanti Research™ - A Croda Brand

Synonyme(s) :

1,2-ditetradecanoyl-sn-glycero-3-phospho-L-serine (sodium salt); DMPS; PS(14:0/14:0)

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A propos de cet article

Formule empirique (notation de Hill) :
C34H65NO10PNa
Numéro CAS:
105405-50-3
Poids moléculaire :
701.84
MDL number:
MFCD00077389
UNSPSC Code:
51191904
NACRES:
NA.25
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description

1,2-dimyristoyl-sn-glycero-3-phospho-L-serine (sodium salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840033P-10mg), pkg of 1 × 200 mg (840033P-200mg), pkg of 1 × 25 mg (840033P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C34H66NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-32(36)42-27-30(28-43-46(40,41)44-29-31(35)34(38)39)45-33(37)26-24-22-20-18-16-14-12-10-8-6-4-2;/h30-31H,3-29,35H2,1-2H3,(H,38,39)(H,40,41);/q;+1/p-1/t30-,31+;/m1./s1

InChI key

QSHQBWBFNCFHLO-MFABWLECSA-M

General description

Phosphatidylserine (PS) is a retinal phospholipid, which carries long-chain highly unsaturated fatty acyl groups.

Application

14:0 PS may be used as an internal standard for spiking serum lipid samples for liquid chromatography-mass spectroscopy analysis and as a component in the phospholipid monolayer to mimic model cancer cell membrane for the anticancer drug doxorubicin (DOx) interaction studies. It has been used in lipid binding assay to assess the binding of monoclonal antibodies (mAbs).

Biochem/physiol Actions

Phosphatidylserine (PS) helps to activate protein kinase C (PKC). It may possess anti-inflammatory properties. PS is also known to participate in tyrosine hydroxylase activation. It is also involved in the uptake of Ca2+ and glucose.

Packaging

5 mL Amber Glass Screw Cap Vial (840033P-10mg)
5 mL Amber Glass Screw Cap Vial (840033P-200mg)
5 mL Amber Glass Screw Cap Vial (840033P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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B Fichtl et al.
Langmuir : the ACS journal of surfaces and colloids, 34(16), 4914-4919 (2018-04-04)
Currently, biological signaling is envisaged as a combination of activation and movement, triggered by local molecular interactions and molecular diffusion, respectively. However, here, we suggest that other fundamental physical mechanisms might play an at least equally important role. We have
Cognitive Effects of Nutraceuticals
Nutraceuticals, 29-48 (2016)
Regina Adão et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183314-183314 (2020-04-19)
α-Synuclein (αsyn) is a cytosolic intrinsically disordered protein (IDP) known to fold into an α-helical structure when binding to membrane lipids, decreasing protein aggregation. Model membrane enable elucidation of factors critically affecting protein folding/aggregation, mostly using either small unilamellar vesicles
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Numéro d'article de commerce international

RéférenceGTIN
840033P-200MG04061835228584
840033P-10MG04061835228577
840033P-25MG04061835228591